JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation

Objectives Macrophage subsets, activated by T cells, are increasingly recognised to play a central role in rheumatoid arthritis (RA) pathogenesis. Janus kinase (JAK) inhibitors have proven beneficial clinical effects in RA. In this study, we investigated the effect of JAK inhibitors on the generatio...

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Bibliographic Details
Main Authors: Iain B McInnes, Duncan Porter, Stefan Siebert, Carl S Goodyear, Jagtar Singh Nijjar, Derek S Gilchrist, Marina Frleta-Gilchrist, Mukanthu H Nyirenda
Format: Article
Language:English
Published: BMJ Publishing Group 2023-01-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/9/1/e002671.full