Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes

Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes

Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin–hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host. CyaA subverts host phagocytic cells by an orchestrated action of its functional domains, where an extremely cat...

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Bibliographic Details
Main Authors: Jakub Novak, Ondrej Cerny, Adriana Osickova, Irena Linhartova, Jiri Masin, Ladislav Bumba, Peter Sebo, Radim Osicka
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Toxins
Subjects:
adenylate cyclase toxin
Bordetella
β2 integrins
cAMP
CD11b/CD18
cell signaling
complement receptor 3
innate immunity
membrane pores
repeats-in-toxin
Online Access:https://www.mdpi.com/2072-6651/9/10/300

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https://www.mdpi.com/2072-6651/9/10/300

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