Effects of Chirality on the Antifungal Potency of Methylated Succinimides Obtained by Aspergillus fumigatus Biotransformations. Comparison with Racemic Ones

Effects of Chirality on the Antifungal Potency of Methylated Succinimides Obtained by Aspergillus fumigatus Biotransformations. Comparison with Racemic Ones

Eighteen (3R) and (3R,4R)-N-phenyl-, N-phenylalkyl and N-arylsuccinimides were prepared with high enantioselectivity by biotransformation of maleimides with A. fumigatus. This environmentally friendly, clean and economical procedure was performed by the whole-cell fungal bioconversion methodology. T...

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Bibliographic Details
Main Authors: Susana Zacchino, Agustina Postigo, Maximiliano Sortino
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
biotransformation
Aspergillus fumigatus
enantioselective reduction
enhanced antifungal activity
chiral succinimides
methylated succinimides
Online Access:http://www.mdpi.com/1420-3049/18/5/5669

Internet

http://www.mdpi.com/1420-3049/18/5/5669

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