Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones

Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones

Neuromuscular blocking agents (NMBAs) like atracurium and rocuronium as well as fluoroquinolones (FQs) cause mast cell-mediated anaphylaxis by activating Mas-related G protein-coupled receptor X2 (MRGPRX2), but many questions remain unanswered. Here, we address three of them, namely whether primary...

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Bibliographic Details
Main Authors: Jessy Elst, Marcus Maurer, Vito Sabato, Margaretha A. Faber, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Athina L. Van Gasse, Marie-Line M. van der Poorten, Leander P. De Puysseleyr, Margo M. Hagendorens, Viggo F. Van Tendeloo, Eva Lion, Diana Campillo-Davo, Didier G. Ebo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
MRGPRX2
IgE
mast cell
drug
anaphylaxis
CD63
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.668962/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.668962/full

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