Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila

Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila

Parkinson's disease (PD) provokes bradykinesia, resting tremor, rigidity and postural instability, and also non-motor symptoms such as depression, anxiety, sleep and cognitive impairments. Similar phenotypes can be induced in Drosophila melanogaster through modification of PD-relevant genes or...

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Bibliographic Details
Main Authors: Stephanie M. Pütz, Jette Kram, Elisa Rauh, Sophie Kaiser, Romy Toews, Yi Lueningschroer-Wang, Dirk Rieger, Thomas Raabe
Format: Article
Language:English
Published: The Company of Biologists 2021-06-01
Series:Disease Models & Mechanisms
Subjects:
drosophila
parkinson's disease
mbt
pak4
negative geotaxis
sleep fragmentation
life expectancy
emotional behavior
dopaminergic pam cluster neurons
Online Access:http://dmm.biologists.org/content/14/6/dmm047811

Internet

http://dmm.biologists.org/content/14/6/dmm047811

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