Flt1 produced by lung endothelial cells impairs ATII cell transdifferentiation and repair in pulmonary fibrosis

Flt1 produced by lung endothelial cells impairs ATII cell transdifferentiation and repair in pulmonary fibrosis

Abstract Pulmonary fibrosis is a devastating disease, in which fibrotic tissue progressively replaces lung alveolar structure, resulting in chronic respiratory failure. Alveolar type II cells act as epithelial stem cells, being able to transdifferentiate into alveolar type I cells, which mediate gas...

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Bibliographic Details
Main Authors: Maria Concetta Volpe, Giulio Ciucci, Giulia Zandomenego, Roman Vuerich, Nadja Anneliese Ruth Ring, Simone Vodret, Francesco Salton, Pietro Marchesan, Luca Braga, Thomas Marcuzzo, Rossana Bussani, Andrea Colliva, Silvano Piazza, Marco Confalonieri, Serena Zacchigna
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05962-2

Internet

https://doi.org/10.1038/s41419-023-05962-2

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