Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice

Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed Zn<sup>2+</sup>-metallopeptidase that regulates hepatic insulin sensitivity, albeit its regulation in response to the fasting-to-postprandial transition is poorly understood. In this work, we studied the regu...

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Bibliographic Details
Main Authors: Carlos M. González-Casimiro, Patricia Cámara-Torres, Beatriz Merino, Sergio Diez-Hermano, Tamara Postigo-Casado, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
insulin-degrading enzyme
fasting
refeeding
insulin resistance
liver
metabolic adaptations
Online Access:https://www.mdpi.com/2073-4409/10/9/2446

Internet

https://www.mdpi.com/2073-4409/10/9/2446

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