Evidence for immune activation in pathogenesis of the HLA class II associated disease, podoconiosis

Abstract Available evidences suggest that podoconiosis is triggered by long term exposure of bare feet to volcanic red clay soil particles. Previous genome-wide studies in Ethiopia showed association between the HLA class II region and disease susceptibility. However, functional relationships betwee...

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Bibliographic Details
Main Authors: Mikias Negash, Menberework Chanyalew, Tigist Girma, Fekadu Alemu, Diana Alcantara, Ben Towler, Gail Davey, Rosemary J. Boyton, Daniel M. Altmann, Rawleigh Howe, Melanie J. Newport
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46347-z