In Silico simulation of Cytochrome P450-Mediated metabolism of aromatic amines: A case study of N-Hydroxylation

In Silico simulation of Cytochrome P450-Mediated metabolism of aromatic amines: A case study of N-Hydroxylation

Aromatic amines, the widely used raw materials in industry, cause long-term exposure to human bodies. They can be metabolized by cytochrome P450 enzymes to form active electrophilic compounds, which will potentially react with nucleophilic DNA to exert carcinogenesis. The short lifetime and versatil...

Full description

Bibliographic Details
Main Authors: Huanni Zhang, Chenchen Wang, Fangjie Guo, Lingmin Jin, Runqian Song, Fangxing Yang, Li Ji, Haiying Yu
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Aromatic amines
Cytochrome P450 enzymes
Activation energy
Bond dissociation energy
Hydroxylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322003840

Internet

http://www.sciencedirect.com/science/article/pii/S0147651322003840

Similar Items