Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1α

<p>Abstract</p> <p>Background</p> <p>Searching for novel molecular markers that dependably predict or indicate responses of human cancer cells to epidermal growth factor receptor (EGFR)-targeted therapy is strongly warranted. The purpose of the current study was to eval...

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Bibliographic Details
Main Authors: Li Xinqun, Liang Ke, Lu Yang, Fan Zhen
Format: Article
Language:English
Published: BMC 2007-10-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/6/1/63