Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins

Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins

Tail-anchored (TA) proteins insert post-translationally into the endoplasmic reticulum (ER), the outer mitochondrial membrane (OMM) and peroxisomes. Whereas the GET pathway controls ER-targeting, no dedicated factors are known for OMM insertion, posing the question of how accuracy is achieved. The m...

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Bibliographic Details
Main Authors: Verena Dederer, Anton Khmelinskii, Anna Gesine Huhn, Voytek Okreglak, Michael Knop, Marius K Lemberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
AAA-ATPase Msp1
mitochondrial protein homeostasis
E3 ubiquitin protein ligase Doa10
endoplasmic reticulum-associated degradation
orphan protein complex subunit
Online Access:https://elifesciences.org/articles/45506

Internet

https://elifesciences.org/articles/45506

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