Interplay Between the IL-33/ST2 Axis and Bone Marrow ILC2s in Protease Allergen-Induced IL-5-Dependent Eosinophilia

Interplay Between the IL-33/ST2 Axis and Bone Marrow ILC2s in Protease Allergen-Induced IL-5-Dependent Eosinophilia

Background: Eosinophils develop from CD34+ progenitor cells in the bone marrow under the influence of interleukin (IL)-5. Several cell types produce IL-5, including type 2 innate lymphoid cells (ILC2s). The alarmin cytokine IL-33 is known to activate ILC2s in mucosal tissues, but little is known abo...

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Bibliographic Details
Main Authors: Emma Boberg, Kristina Johansson, Carina Malmhäll, Jenny Calvén, Julie Weidner, Madeleine Rådinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
allergy
papain
bone marrow
eosinophilia
interleukin-33
interleukin-5
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01058/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01058/full

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