Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response

Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response

Epigenetic alterations are implicated in tumour immune evasion and immune checkpoint blockade (ICB) resistance. SET domain bifurcated histone methyltransferase 1 (SETDB1) is a histone lysine methyltransferase that catalyses histone H3K9 di- and tri-methylation on euchromatin, and growing evidence in...

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Bibliographic Details
Main Authors: Zhipeng Zhao, Lu Feng, Xuerun Peng, Tingnan Ma, Rongsheng Tong, Lei Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
SETDB1
immune escape
immune checkpoint blockade resistance
endogenous retrovirus
epigenetic therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1073713/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1073713/full

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