Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients

Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients

The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation. This study aimed to determine urinary properdin and sC5b-9 excretion a...

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Bibliographic Details
Main Authors: Rosa G. M. Lammerts, Michele F. Eisenga, Mohammed Alyami, Mohamed R. Daha, Marc A. Seelen, Robert A. Pol, Jacob van den Born, Jan-Stephan Sanders, Stephan J. L. Bakker, Stefan P. Berger
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
transplantation
chronic renal failure
properdin
C5b-9
complement activation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02511/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02511/full

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