JAK/STAT as a Potential Therapeutic Target for Osteolytic Diseases

JAK/STAT as a Potential Therapeutic Target for Osteolytic Diseases

Several cytokines with major biological functions in inflammatory diseases exert their functions through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signal transduction pathway. JAKs phosphorylate the cytoplasmic domain of the receptor, inducing the activation of i...

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Bibliographic Details
Main Authors: Mariely A. Godoi, Angelo C. Camilli, Karen G. A. Gonzales, Vitória B. Costa, Evangelos Papathanasiou, Fábio R. M. Leite, Morgana R. Guimarães-Stabili
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
JAK/STAT inhibitor
osteoclasts
osteoblasts
cytokines
JAK/STAT signaling pathway
osteolysis
Online Access:https://www.mdpi.com/1422-0067/24/12/10290

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https://www.mdpi.com/1422-0067/24/12/10290

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