A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells

A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells

Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins.

Bibliographic Details
Main Authors: Ya Zhang, Liang Huang, Haiqing Fu, Owen K. Smith, Chii Mei Lin, Koichi Utani, Mishal Rao, William C. Reinhold, Christophe E. Redon, Michael Ryan, RyangGuk Kim, Yang You, Harlington Hanna, Yves Boisclair, Qiaoming Long, Mirit I. Aladjem
Format: Article
Language:English
Published: Nature Portfolio 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11748

Internet

https://doi.org/10.1038/ncomms11748

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