Advances in CRISPR/Cas gene therapy for inborn errors of immunity

Advances in CRISPR/Cas gene therapy for inborn errors of immunity

Inborn errors of immunity (IEIs) are a group of inherited disorders caused by mutations in the protein-coding genes involved in innate and/or adaptive immunity. Hematopoietic stem cell transplantation (HSCT) is a mainstay definitive therapy for many severe IEIs. However, the lack of HLA-matched dono...

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Bibliographic Details
Main Authors: Xinyi Liu, Guanglei Li, Yin Liu, Fuling Zhou, Xingxu Huang, Kui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
inborn errors of immunity (IEIs)
Primary Immunodeficiencies (PIDs)
CRISPR/Cas
gene therapy
gene editing
base editing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111777/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111777/full

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