Limitations of PLX3397 as a microglial investigational tool: peripheral and off-target effects dictate the response to inflammation

Limitations of PLX3397 as a microglial investigational tool: peripheral and off-target effects dictate the response to inflammation

Microglia, the resident macrophages of the central nervous system (CNS), play a critical role in CNS homeostasis and neuroinflammation. Pexidartinib (PLX3397), a colony-stimulating factor 1 (CSF1) receptor inhibitor, is widely used to deplete microglia, offering flexible options for both long-term d...

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Bibliographic Details
Main Authors: Wouter Claeys, Daan Verhaege, Griet Van Imschoot, Elien Van Wonterghem, Lore Van Acker, Laura Amelinck, Federico F. De Ponti, Charlotte Scott, Anja Geerts, Christophe Van Steenkiste, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
microglia
bile duct ligation (BDL)
endotoxemia
lipopolysaccharide (LPS)
PLX3397
peripheral inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1283711/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1283711/full

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