A structured model and likelihood approach to estimate yeast prion propagon replication rates and their asymmetric transmission.
Prion proteins cause a variety of fatal neurodegenerative diseases in mammals but are generally harmless to Baker's yeast (Saccharomyces cerevisiae). This makes yeast an ideal model organism for investigating the protein dynamics associated with these diseases. The rate of disease onset is rela...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-07-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1010107 |