Development of 225Ac-doped biocompatible nanoparticles for targeted alpha therapy

Development of 225Ac-doped biocompatible nanoparticles for targeted alpha therapy

Abstract Targeted alpha therapy (TAT) relies on chemical affinity or active targeting using radioimmunoconjugates as strategies to deliver α-emitting radionuclides to cancerous tissue. These strategies can be affected by transmetalation of the parent radionuclide by competing ions in vivo and the bo...

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Bibliographic Details
Main Authors: Miguel Toro-González, Ngozi Akingbesote, Amber Bible, Debjani Pal, Brian Sanders, Alexander S. Ivanov, Santa Jansone-Popova, Ilja Popovs, Paul Benny, Rachel Perry, Sandra Davern
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Journal of Nanobiotechnology
Subjects:
Actinium-225
Poly(lactic-co-glycolic acid)
Nanoparticles
Therapy
Ligand
Online Access:https://doi.org/10.1186/s12951-024-02520-6

Internet

https://doi.org/10.1186/s12951-024-02520-6

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