Integration of Immune Cell Populations, mRNA-Seq, and CpG Methylation to Better Predict Humoral Immunity to Influenza Vaccination: Dependence of mRNA-Seq/CpG Methylation on Immune Cell Populations

Integration of Immune Cell Populations, mRNA-Seq, and CpG Methylation to Better Predict Humoral Immunity to Influenza Vaccination: Dependence of mRNA-Seq/CpG Methylation on Immune Cell Populations

The development of a humoral immune response to influenza vaccines occurs on a multisystems level. Due to the orchestration required for robust immune responses when multiple genes and their regulatory components across multiple cell types are involved, we examined an influenza vaccination cohort us...

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Bibliographic Details
Main Authors: Gregory A. Poland, Michael T. Zimmermann, Richard B. Kennedy, Diane E. Grill, Ann L. Oberg, Krista M. Goergen, Inna G. Ovsyannikova, Iana H. Haralambieva
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Immunology
Subjects:
influenza vaccine
data mining
machine learning
cell sorting
methylation
differential expression
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00445/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00445/full

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