Role of Helical Structure in MBP Immunodominant Peptides for Efficient IgM Antibody Recognition in Multiple Sclerosis

Role of Helical Structure in MBP Immunodominant Peptides for Efficient IgM Antibody Recognition in Multiple Sclerosis

The involvement of Myelin Basic Protein (MBP) in Multiple Sclerosis (MS) has been widely discussed in the literature. This intrinsically disordered protein has an interesting α-helix motif, which can be considered as a conformational epitope. In this work we investigate the importance of the helical...

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Bibliographic Details
Main Authors: Agnieszka Staśkiewicz, Michael Quagliata, Feliciana Real-Fernandez, Francesca Nuti, Roberta Lanzillo, Vincenzo Brescia-Morra, Hendrik Rusche, Michal Jewginski, Alfonso Carotenuto, Diego Brancaccio, Rina Aharoni, Ruth Arnon, Paolo Rovero, Rafal Latajka, Anna Maria Papini
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Chemistry
Subjects:
multiple sclerosis
circular dichroism
immune response
synthetic helical peptides
myelin basic protein antigen
peptide-antigen based ELISA
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.885180/full

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https://www.frontiersin.org/articles/10.3389/fchem.2022.885180/full

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