Transcription factor XBP1s promotes endometritis-induced epithelial-mesenchymal transition by targeting MAP3K2, a key gene in the MAPK/ERK pathway

Transcription factor XBP1s promotes endometritis-induced epithelial-mesenchymal transition by targeting MAP3K2, a key gene in the MAPK/ERK pathway

Abstract The epithelial-mesenchymal transition (EMT) is a biological process whereby epithelial cells are transformed into cells with a mesenchymal phenotype. The transcription factor, X-box binding protein 1 splicing variant (XBP1s) is a key regulator of the endoplasmic reticulum stress response (E...

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Bibliographic Details
Main Authors: Kangkang Gao, Mengqi Si, Xinxi Qin, Beibei Zhang, Zongjie Wang, Pengfei Lin, Huatao Chen, Aihua Wang, Yaping Jin
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
XBP1s
Epithelial-mesenchymal transition
Endoplasmic reticulum stress
CUT & Tag
Molecular docking
MAPK/ERK pathway
Online Access:https://doi.org/10.1186/s12964-025-02050-0

Internet

https://doi.org/10.1186/s12964-025-02050-0

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