Effects of adrenergic-stimulated lipolysis and cytokine production on in vitro mouse adipose tissue–islet interactions

Abstract Inflammatory cytokines and non-esterified fatty acids (NEFAs) are obesity-linked factors that disturb insulin secretion. The aim of this study was to investigate whether pancreatic adipose tissue (pWAT) is able to generate a NEFA/cytokine overload within the pancreatic environment and as co...

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Bibliographic Details
Main Authors: Morgana Barroso Oquendo, Estela Lorza-Gil, David Juarez-Lopez, Robert Wagner, Andreas L. Birkenfeld, Susanne Ullrich, Felicia Gerst
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18262-0