A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys

A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys

Abstract Background Hematopoietic stem cell (HSC) transplantation is an effective treatment strategy for many types of diseases. Peripheral blood (PB) is the most commonly used source of bone marrow (BM)-derived stem cells for current HSC transplantation. However, PB usually contains very few HSCs u...

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Bibliographic Details
Main Authors: Xiao Fang, Xiong Fang, Yujia Mao, Aaron Ciechanover, Yan Xu, Jing An, Ziwei Huang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Hematopoietic stem cell mobilization
CXCR4 antagonist
Monkeys
Hematopoietic stem cell transplantation
Online Access:https://doi.org/10.1186/s13287-020-02073-z

Internet

https://doi.org/10.1186/s13287-020-02073-z

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