What Is Abnormal in Normal Karyotype Acute Myeloid Leukemia in Children? Analysis of the Mutational Landscape and Prognosis of the TARGET-AML Cohort

What Is Abnormal in Normal Karyotype Acute Myeloid Leukemia in Children? Analysis of the Mutational Landscape and Prognosis of the TARGET-AML Cohort

Normal karyotype acute myeloid leukemia (NK-AML) constitutes 20–25% of pediatric AML and detailed molecular analysis is essential to unravel the genetic background of this group. Using publicly available sequencing data from the TARGET-AML initiative, we investigated the mutational landscape of NK-A...

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Bibliographic Details
Main Authors: Morten Krogh Herlin, Sara A. Yones, Eigil Kjeldsen, Linda Holmfeldt, Henrik Hasle
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Genes
Subjects:
pediatric acute myeloid leukemia
normal karyotype
cytogenetically normal
mutational landscape
molecular genetics
cytogenetics
Online Access:https://www.mdpi.com/2073-4425/12/6/792

Internet

https://www.mdpi.com/2073-4425/12/6/792

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