Isotretinoin self-nano-emulsifying drug delivery system: Preparation, optimization and antibacterial evaluation

Isotretinoin self-nano-emulsifying drug delivery system: Preparation, optimization and antibacterial evaluation

Purpose: Isotretinoin (ITN) is a poorly water-soluble drug. The objective of this study was to design a successful liquid self-nanoemulsifying drug delivery system (L-SNEDDS) for ITN to improve its solubility, dissolution rate, and antibacterial activity. Methods: According to solubility and emulsif...

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Bibliographic Details
Main Authors: Rihaf Alfaraj, Sandra Hababah, Esra K. Eltayb, Fulwah Y. Alqahtani, Fadilah S. Aleanizy
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Saudi Pharmaceutical Journal
Subjects:
LSNEDDS (liquid self-nanoemulsifying system)
Isotretinoin (ITN)
In vitro dissolution Staphylococcus aureus
MRSA (methicillin-resistant Staphylococcus aureus)
Solubility
Antibacterial activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016424001130

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http://www.sciencedirect.com/science/article/pii/S1319016424001130

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