N6-Methyladenosine Induced miR-34a-5p Promotes TNF-α-Induced Nucleus Pulposus Cell Senescence by Targeting SIRT1

N6-Methyladenosine Induced miR-34a-5p Promotes TNF-α-Induced Nucleus Pulposus Cell Senescence by Targeting SIRT1

Low back pain is tightly associated with intervertebral disc degeneration (IVDD) and aberrant nucleus pulposus (NP) is a critical cause. miRNAs N6-methyladenosine (m6A) modification accounts for the TNF-α-induced senescence of NP cells. The aim of this study was to investigate whether m6A modificati...

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Bibliographic Details
Main Authors: Hao Zhu, Bao Sun, Liang Zhu, Guoyou Zou, Qiang Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
N6-methyladenosine
IVDD
miR-34a-5p
cell senescence
SIRT1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.642437/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.642437/full

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