First-Row Transition Metal Complexes Incorporating the 2-(2′-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

First-Row Transition Metal Complexes Incorporating the 2-(2′-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

Inflammatory mediators constitute a recently coined term in the field of metal-based complexes with antiplatelet activities. Our strategy targets Platelet-Activating Factor (PAF) and its receptor, which is the most potent lipid mediator of inflammation. Thus, the antiplatelet (anti-PAF) potency of a...

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Bibliographic Details
Main Authors: Antigoni Margariti, Vasiliki D. Papakonstantinou, George M. Stamatakis, Constantinos A. Demopoulos, Christina Machalia, Evangelia Emmanouilidou, Gregor Schnakenburg, Maria-Christina Nika, Nikolaos S. Thomaidis, Athanassios I. Philippopoulos
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molecules
Subjects:
metal complex
first-row transition metals
2-(2′-pyridyl)quinoxaline
Platelet-Activating Factor
thrombin
PAF-inhibitors
Online Access:https://www.mdpi.com/1420-3049/28/19/6899

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https://www.mdpi.com/1420-3049/28/19/6899

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