Intrathecal Methotrexate-Induced Necrotizing Myelopathy: A Case Report and Review of Histologic Features

Central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL) is associated with a poor prognosis. However, prophylactic measures, including intrathecal (IT) methotrexate, reduce the incidence of CNS relapse in these patients considerably. Unfortunately, IT methotrexate can cause severa...

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Bibliographic Details
Main Authors: Hamza Tariq, Andrea Gilbert, Francis E Sharkey
Format: Article
Language:English
Published: SAGE Publishing 2018-11-01
Series:Clinical Medicine Insights: Pathology
Online Access:https://doi.org/10.1177/1179555718809071