Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones

Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones

The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). Th...

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Bibliographic Details
Main Authors: Xue Yan, Ying-De Tang, Cheng-Shi Jiang, Xigong Liu, Hua Zhang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
cross coupling
dearomatization
c-h functionalization
indolin-3-ones
dimerization and trimerization of indoles
Online Access:https://www.mdpi.com/1420-3049/25/2/419

Internet

https://www.mdpi.com/1420-3049/25/2/419

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