Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones
The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). Th...
| Main Authors: | , , , , |
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| Format: | Article |
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MDPI AG
2020-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/2/419 |
| _version_ | 1819140844874104832 |
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| author | Xue Yan Ying-De Tang Cheng-Shi Jiang Xigong Liu Hua Zhang |
| author_facet | Xue Yan Ying-De Tang Cheng-Shi Jiang Xigong Liu Hua Zhang |
| author_sort | Xue Yan |
| collection | DOAJ |
| description | The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles has also been demonstrated under the same conditions. |
| first_indexed | 2024-12-22T11:45:01Z |
| format | Article |
| id | doaj.art-c732bb06e0164e799ed3ecc832d4261c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T11:45:01Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c732bb06e0164e799ed3ecc832d4261c2022-12-21T18:27:09ZengMDPI AGMolecules1420-30492020-01-0125241910.3390/molecules25020419molecules25020419Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-onesXue Yan0Ying-De Tang1Cheng-Shi Jiang2Xigong Liu3Hua Zhang4School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, ChinaSchool of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, ChinaSchool of Biological Science and Technology, University of Jinan, Jinan 250022, ChinaSchool of Biological Science and Technology, University of Jinan, Jinan 250022, ChinaSchool of Biological Science and Technology, University of Jinan, Jinan 250022, ChinaThe oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles has also been demonstrated under the same conditions.https://www.mdpi.com/1420-3049/25/2/419cross couplingdearomatizationc-h functionalizationindolin-3-onesdimerization and trimerization of indoles |
| spellingShingle | Xue Yan Ying-De Tang Cheng-Shi Jiang Xigong Liu Hua Zhang Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones Molecules cross coupling dearomatization c-h functionalization indolin-3-ones dimerization and trimerization of indoles |
| title | Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones |
| title_full | Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones |
| title_fullStr | Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones |
| title_full_unstemmed | Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones |
| title_short | Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones |
| title_sort | oxidative dearomative cross dehydrogenative coupling of indoles with diverse c h nucleophiles efficient approach to 2 2 disubstituted indolin 3 ones |
| topic | cross coupling dearomatization c-h functionalization indolin-3-ones dimerization and trimerization of indoles |
| url | https://www.mdpi.com/1420-3049/25/2/419 |
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