Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesiss⃞

Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesiss⃞

Stimulated inflammatory cells synthesize platelet-activating factor (PAF), but lysates of these cells show little enhancement in PAF synthase activity. We show that human neutrophils contain intracellular plasma PAF acetylhydrolase (PLA2G7), an enzyme normally secreted by monocytes. The esterase inh...

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Bibliographic Details
Main Authors: Jiawei Chen, Lili Yang, Jason M. Foulks, Andrew S. Weyrich, Gopal K. Marathe, Thomas M. McIntyre
Format: Article
Language:English
Published: Elsevier 2007-11-01
Series:Journal of Lipid Research
Subjects:
platelet-activating factor
recycling
methyl arachidonoylfluorophosphonate
Pefabloc
phospholipase
lipoprotein-associated phospholipase A2
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520424368

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http://www.sciencedirect.com/science/article/pii/S0022227520424368

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