Single-Cell DNA Sequencing and Immunophenotypic Profiling to Track Clonal Evolution in an Acute Myeloid Leukemia Patient

Single-Cell DNA Sequencing and Immunophenotypic Profiling to Track Clonal Evolution in an Acute Myeloid Leukemia Patient

Single-cell DNA sequencing can address the sequence of somatic genetic events during myeloid transformation in relapsed acute myeloid leukemia (AML). We present an <i>NPM1</i>-mutated AML patient with an initial low ratio of <i>FLT3</i>-ITD (low-risk ELN-2017), treated with m...

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Bibliographic Details
Main Authors: María García-Álvarez, Ana Yeguas, Cristina Jiménez, Alejandro Medina-Herrera, Verónica González-Calle, Montserrat Hernández-Ruano, Rebeca Maldonado, Irene Aires, Cristina Casquero, Inmaculada Sánchez-Villares, Ana Balanzategui, María Eugenia Sarasquete, Miguel Alcoceba, María Belén Vidriales, Marcos González-Díaz, Ramón García-Sanz, María Carmen Chillón
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomedicines
Subjects:
acute myeloid leukemia
<i>FLT3</i>-ITD
single-cell DNA sequencing
next-generation sequencing
immunophenotype
midostaurin
Online Access:https://www.mdpi.com/2227-9059/12/1/66

Internet

https://www.mdpi.com/2227-9059/12/1/66

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