The extracellular matrix protein fibulin-3/EFEMP1 promotes pleural mesothelioma growth by activation of PI3K/Akt signaling

The extracellular matrix protein fibulin-3/EFEMP1 promotes pleural mesothelioma growth by activation of PI3K/Akt signaling

Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis and limited therapeutic options. The extracellular matrix protein fibulin-3/EFEMP1 accumulates in the pleural effusions of MPM patients and has been proposed as a prognostic biomarker of these tumors. However, it is enti...

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Bibliographic Details
Main Authors: Arivazhagan Roshini, Chandra Goparaju, Somanath Kundu, Mohan S. Nandhu, Sharon L. Longo, John A. Longo, Joan Chou, Frank A. Middleton, Harvey I. Pass, Mariano S. Viapiano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
mesothelioma
extracellular matrix
tumor microenvironment
PI3k signaling
antibody therapy
fibulin family
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1014749/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1014749/full

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