Oxidation of Phospholipids by OH Radical Coordinated to Copper Amyloid-β Peptide—A Density Functional Theory Modeling

Oxidation of Phospholipids by OH Radical Coordinated to Copper Amyloid-β Peptide—A Density Functional Theory Modeling

Oxidative stress and metal dyshomeostasis are considered crucial factors in the pathogenesis of Alzheimer’s disease (AD). Indeed, transition metal ions such as Cu(II) can generate reactive oxygen species (ROS) via O<sub>2</sub> Fenton-like reduction, catalyzed by Cu(II) coordinated to th...

Full description

Bibliographic Details
Main Authors: Alberto Rovetta, Laura Carosella, Federica Arrigoni, Jacopo Vertemara, Luca De Gioia, Giuseppe Zampella, Luca Bertini
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Inorganics
Subjects:
copper amyloid peptide
Alzheimer’s disease
oxidative stress
CuAβ hypothesis
phospholipid membrane
Density Functional Theory
Online Access:https://www.mdpi.com/2304-6740/11/6/227

Internet

https://www.mdpi.com/2304-6740/11/6/227

Similar Items