USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis

USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis

Duodenogastric reflux (DGR) has been linked to the onset of gastric cancer (GC), although the precise mechanism is yet obscure. Herein, we aimed to investigate how refluxed bile acids (BAs) and macrophages are involved in gastric carcinogenesis. In both active human bile reflux gastritis and the mur...

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Bibliographic Details
Main Authors: Chenye Zhao, Mingchao Mu, Xiaopeng Li, Zepeng Dong, Jiahao Wang, Chengzhi Yao, Jianbao Zheng, Xuejun Sun, Junhui Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
USP50
gastric tumorigenesis
NLRP3 inflammasome
pyroptosis
HMGB1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1326137/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1326137/full

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