Notopterol Suppresses IL-17-Induced Proliferation and Invasion of A549 Lung Adenocarcinoma Cells via Modulation of STAT3, NF-κB, and AP-1 Activation

Notopterol Suppresses IL-17-Induced Proliferation and Invasion of A549 Lung Adenocarcinoma Cells via Modulation of STAT3, NF-κB, and AP-1 Activation

Interleukine-17 is a proinflammatory cytokine that promotes lung cancer growth and progression though the activation of the STAT3, NF-κB, and AP-1 signaling pathways. Therefore, blocking the IL-17-induced oncogenic pathway is a new strategy for the treatment of lung cancer. Notopterol, a furanocouma...

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Bibliographic Details
Main Authors: Sirinada Inthanon, Pornngarm Dejkriengkraikul, Supachai Yodkeeree
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
notopterol
interleukine-17
A549 cells
proliferation
invasion
MAPKs
Online Access:https://www.mdpi.com/1422-0067/24/20/15057

Internet

https://www.mdpi.com/1422-0067/24/20/15057

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