Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection

Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection

The success of siRNA-based therapeutics highly depends on a safe and efficient delivery of siRNA into the cytosol. In this study, we post-modified the primary amines on dendritic polyglycerolamine (dPG-NH2) with different ratios of two relevant amino acids, namely, arginine (Arg) and histidine (His)...

Full description

Bibliographic Details
Main Authors: Fatemeh Sheikhi Mehrabadi, Hanxiang Zeng, Mark Johnson, Cathleen Schlesener, Zhibin Guan, Rainer Haag
Format: Article
Language:English
Published: Beilstein-Institut 2015-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
arginine
dendritic polyglycerolamine
histidine
multivalent vector
siRNA delivery
Online Access:https://doi.org/10.3762/bjoc.11.86

Internet

https://doi.org/10.3762/bjoc.11.86

Similar Items