Development of a Sensitive Digital Droplet PCR Screening Assay for the Detection of <i>GPR126</i> Non-Coding Mutations in Bladder Cancer Urine Liquid Biopsies

Development of a Sensitive Digital Droplet PCR Screening Assay for the Detection of <i>GPR126</i> Non-Coding Mutations in Bladder Cancer Urine Liquid Biopsies

Recent whole-genome sequencing studies identified two novel recurrent mutations in the enhancer region of <i>GPR126</i> in urothelial bladder cancer (UBC) tumor samples. This mutational hotspot is the second most common after the <i>TERT</i> promoter in UBC. The aim of the st...

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Bibliographic Details
Main Authors: Mark Jain, Alexander Tivtikyan, David Kamalov, Savva Avdonin, Tagir Rakhmatullin, Eduard Pisarev, Maria Zvereva, Larisa Samokhodskaya, Armais Kamalov
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
liquid biopsy
urine
bladder cancer
digital droplet polymerase chain reaction
<i>TERT</i> promoter
<i>GPR126</i>
Online Access:https://www.mdpi.com/2227-9059/11/2/495

Internet

https://www.mdpi.com/2227-9059/11/2/495

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