Development and Application of a Nanobody-Based Competitive ELISA for Detecting Antibodies against Hepatitis E Virus from Humans and Domestic Animals

Development and Application of a Nanobody-Based Competitive ELISA for Detecting Antibodies against Hepatitis E Virus from Humans and Domestic Animals

ABSTRACT Hepatitis E virus (HEV) is a zoonotic pathogen that is widespread worldwide. At present, most enzyme-linked immunosorbent assay (ELISA) kits only detect antibodies against human HEV. In this study, a nanobody-horseradish peroxidase (HRP) fusion protein-based competitive ELISA (cELISA) with...

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Bibliographic Details
Main Authors: Yiyang Chen, Meimei Zhang, Tianxiang Chen, Jiaxi Wang, Qin Zhao, En-Min Zhou, Baoyuan Liu
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
hepatitis E virus (HEV)
cELISA
antibodies
humans
domestic animals
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03607-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03607-22

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