Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor.

Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor.

During Alzheimer's Disease, sustained exposure to amyloid-β₄₂ oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (C16:0 PAF), but not it...

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Bibliographic Details
Main Authors: Michael A Kennedy, Nazir Kabbani, Jean-Philippe Lambert, Leigh Anne Swayne, Fida Ahmed, Daniel Figeys, Steffany A L Bennett, Jennnifer Bryan, Kristin Baetz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3037409?pdf=render

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http://europepmc.org/articles/PMC3037409?pdf=render

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