Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration

Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration

We recently showed that the post-ischemic induction of matrix metalloproteinase-12 (MMP-12) in the brain degrades tight junction proteins, increases MMP-9 and TNFα expression, and contributes to the blood-brain barrier (BBB) disruption, apoptosis, demyelination, and infarct volume development. The o...

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Bibliographic Details
Main Authors: Siva Reddy Challa, Koteswara Rao Nalamolu, Casimir A. Fornal, Billy C. Wang, Ryan C. Martin, Elsa A. Olson, Ammar L. Ujjainwala, David M. Pinson, Jeffrey D. Klopfenstein, Krishna Kumar Veeravalli
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Neuroscience
Subjects:
ischemia
reperfusion
matrix metalloproteinase-12
sensory
motor
recovery
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1012812/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.1012812/full

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