Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta

Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta

Abstract Background The human placenta is distinct from most organs due to its uniquely low-methylated genome. DNA methylation (DNAme) is particularly depleted in the placenta at partially methylated domains and on the inactive X chromosome (Xi) in XX samples. While Xi DNAme is known to be critical...

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Bibliographic Details
Main Authors: Amy M Inkster, Allison M Matthews, Tanya N Phung, Seema B Plaisier, Melissa A Wilson, Carolyn J Brown, Wendy P Robinson
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biology of Sex Differences
Subjects:
DNA methylation
X-chromosome inactivation
Placenta
Prenatal development
Sex differences
Online Access:https://doi.org/10.1186/s13293-025-00696-6

Internet

https://doi.org/10.1186/s13293-025-00696-6

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