Epicutaneous Administration of Papain Induces IgE and IgG Responses in a Cysteine Protease Activity-Dependent Manner

Epicutaneous Administration of Papain Induces IgE and IgG Responses in a Cysteine Protease Activity-Dependent Manner

Background: Epicutaneous sensitization to allergens is important in the pathogenesis of not only skin inflammation such as atopic dermatitis but also "atopic march" in allergic diseases such as asthma and food allergies. We here examined antibody production and skin barrier dysfunction in...

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Bibliographic Details
Main Authors: Hideo Iida, Toshiro Takai, Yusuke Hirasawa, Seiji Kamijo, Sakiko Shimura, Hirono Ochi, Izumi Nishioka, Natsuko Maruyama, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Allergology International
Subjects:
epicutaneous sensitization
IgE
mouse model
papain
protease allergen
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015300356

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http://www.sciencedirect.com/science/article/pii/S1323893015300356

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