Microvascular Dysfunction in Skeletal Muscle Precedes Myocardial Vascular Changes in Diabetic Cardiomyopathy: Sex-Dependent Differences

Microvascular Dysfunction in Skeletal Muscle Precedes Myocardial Vascular Changes in Diabetic Cardiomyopathy: Sex-Dependent Differences

AimTo uncover sex-related microvascular abnormalities that underlie the early presentation of reduced perfusion in leg skeletal muscle in a type II rat model of diabetic cardiomyopathy.Methods and ResultsDiabetes was induced using a non-obese, diet-based, low-dose streptozotocin model in adult femal...

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Bibliographic Details
Main Authors: Sadi Loai, Xuetao Sun, Mansoor Husain, Michael A. Laflamme, Herman Yeger, Sara S. Nunes, Hai-Ling Margaret Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
heart failure
microvascular dysfunction
skeletal muscle
sex differences
type II diabetes
preserved ejection fraction (HFpEF)
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.886687/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.886687/full

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