Pulmonary Safety Profile of Esc Peptides and Esc-Peptide-Loaded Poly(lactide-co-glycolide) Nanoparticles: A Promising Therapeutic Approach for Local Treatment of Lung Infectious Diseases

Pulmonary Safety Profile of Esc Peptides and Esc-Peptide-Loaded Poly(lactide-co-glycolide) Nanoparticles: A Promising Therapeutic Approach for Local Treatment of Lung Infectious Diseases

In recent years, we have discovered Esc(1-21) and its diastereomer (Esc peptides) as valuable candidates for the treatment of Pseudomonas lung infection, especially in patients with cystic fibrosis (CF). Furthermore, engineered poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) were revealed to b...

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Bibliographic Details
Main Authors: Floriana Cappiello, Bruno Casciaro, Maria Rosa Loffredo, Elena Puglisi, Qiao Lin, Dandan Yang, Gemma Conte, Ivana d’Angelo, Francesca Ungaro, Loretta Ferrera, Raffaella Barbieri, Laura Cresti, Alessandro Pini, Yuanpu Peter Di, Maria Luisa Mangoni
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
antimicrobial peptides
cystic fibrosis
lung infection
biodegradable nanocarrier
therapeutic index
transepithelial resistance
Online Access:https://www.mdpi.com/1999-4923/14/11/2297

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https://www.mdpi.com/1999-4923/14/11/2297

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