Pan-EGFR Inhibitor Dacomitinib Resensitizes Paclitaxel and Induces Apoptosis via Elevating Intracellular ROS Levels in Ovarian Cancer SKOV3-TR Cells

Pan-EGFR Inhibitor Dacomitinib Resensitizes Paclitaxel and Induces Apoptosis via Elevating Intracellular ROS Levels in Ovarian Cancer SKOV3-TR Cells

Paclitaxel is still used as a standard first-line treatment for ovarian cancer. Although paclitaxel is effective for many types of cancer, the emergence of chemoresistant cells represents a major challenge in chemotherapy. Our study aimed to analyze the cellular mechanism of dacomitinib, a pan-epide...

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Bibliographic Details
Main Authors: Ye Jin Lim, Hee Su Kim, Seunghee Bae, Kyeong A So, Tae Jin Kim, Jae Ho Lee
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
dacomitinib
pan-EGFR inhibitor
ovarian cancer
paclitaxel-resistance
reactive oxygen species
Online Access:https://www.mdpi.com/1420-3049/29/1/274

Internet

https://www.mdpi.com/1420-3049/29/1/274

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