The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling

The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling

The dysregulation of ROS production and osteoclastogenesis is involved in the progress of osteoporosis. To identify novel and effective targets to treat this disease, it is important to explore the underlying mechanisms. In our study, we firstly tested the effect of the Nrf2 activator RTA-408, a nov...

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Bibliographic Details
Main Authors: Xuewu Sun, Ziang Xie, Bin Hu, Boya Zhang, Yan Ma, Xin Pan, Hai Huang, Jiying Wang, Xiangde Zhao, Zhiwei Jie, Peihua Shi, Zhijun Chen
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719307141

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http://www.sciencedirect.com/science/article/pii/S2213231719307141

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