Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression- and anxiety-like behavior in mice

Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression- and anxiety-like behavior in mice

Bisphenol A (BPA), a well-known environmental endocrine disruptor, has been implicated in anxiety-like behavior. But the neural mechanism remains elusive. Herein, we found that mice exposed to 0.5 mg/kg/day BPA chronically from postnatal days (PND) 21 to PND 80 exhibited depression- and anxiety-like...

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Bibliographic Details
Main Authors: Rongrong Wang, Zhi-Hua Liu, Nanxi Bi, Xiaozhen Gu, Chengqing Huang, Ruiqing Zhou, Haoyu Liu, Hui-Li Wang
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Bisphenol A (BPA)
Depression- and anxiety-like behavior
Microglial activation
Neuroinflammation
Medial prefrontal cortex (mPFC)
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323005389

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http://www.sciencedirect.com/science/article/pii/S0147651323005389

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